Infectious Bursal Disease and IBDV
Infectious bursal disease (IBD) is caused by infectious bursal disease virus (IBDV) an avian Birnavirus first described in the USA near the town of Gumboro Delaware and thus the disease is also known as Gumboro disease.
There are 3 recognized pathogenic types of IBDV; classic virulent (cvIBDV), sub-clinical (scIBDV), and very virulent (vvIBDV).
All three pathogenic types of IBDV cause immune suppression which leads to secondary infections and a failure to produce an immune response to vaccines.
The cvIBDV typically cause a high morbidity and low mortality disease while the scIBDV cause very little morbidity and no mortality. The vvIBDV cause an acute disease in chickens characterized by high morbidity and high mortality.
New LightCycler Technolgy
Today we are using real-time RT-PCR to detect IBDV. We are able to use probes and dyes to detect the RT-PCR products during a real-time assay.
Sequencing and Phylogenic Analysis
We determine the nucleotide and predicted amino acid sequence of the hypervariable region of VP2 (hvVP2) to identify IBDV strains. Phylogenic analysis using these sequences has provided valuable information into the ancestry of these viruses.
Our lab is committed to improving the health of poultry through research on the prevention, control and diagnosis of IBDV.
Dr. Daral J. Jackwood
Food Animal Health Research Program
Ohio Agricultural Research and Development Center
1680 Madison Ave.
Wooster, Ohio 44691
Phone (330) 263-3964
Fax (330) 263-3677